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Sodium bicarbonate should be used if the pH is below 7.2 (molar bicarbonate infusion via venous a catheter at a dose of 1 to 3 mEq/kg)

21 LarsenE.AlfenitoM.BriggsW.WalbotV

BMC Plant Biol 9:130

The institution where you are practicing will likely have some basic guidelines on initiating warfarin, so when in doubt use those

The trial methodology may not always meet the gold-standard requirements of Western regulatory agencies, but the breadth and consistency of positive findings across multiple studies provides meaningful confidence in its efficacy and safety