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As noted above, Trxs are responsible for reducing Prx back to their reduced, oxidant-scavenging state, while thioredoxin reductases (TrxRDs) keep the reduced state of Trxs using NAPDH reducing equivalents, as depicted in Figure 2

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the culture medium was exchanged by an extracellular solution containing (in mM) 140 NaCl, 2.5 KG, 1 MgCl 2 , 3 CaCI 2 , 25 glucose, and 5 HEPES