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doi: 10.3390/diseases13020059 446 VanVTHLiuZSHsiehYJShiuWCChenBYKuYWet al

Oct 20: Nearly two years ago, the FDA approved BioMarins Voxzogo (vosoritide) as the first therapy for achondroplasia, a rare genetic disorder that causes the most common form of dwarfismfueling ongoing controversy within the dwarfism community about such treatments

The augmented p21 expression, the increased phosphorylation of p53 at serine 15, and the decreased phosphorylation of retinoblastoma (Rb) at serine 780 have all been reported as markers for cell cycle arrest associated with senescence 30,31

A change in half-life will not necessarily reflect a change in drug elimination