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TRH is mainly expressed in the hypothalamus of fish, amphibians, birds and mammals, and has been detected in a number of peripheral tissues in reptiles (74)

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Patients taking other B-vitamin supplements or multivitamin preparations should inform their prescribing provider, as evaluation for potential additive effects or imbalances may be appropriate

67 In line with a role of ATII in endothelial dysfunction and hypertension, numerous studies have now demonstrated that the therapy with angiotensin-converting enzyme inhibitors and AT-1 receptor blockers is associated with an improvements in endothelial responsiveness 68, 69, 70, 71, 72 (the existence of negative reports also needs to be acknowledged)

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