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-GCLC, gamma-glutamylcysteine synthetase

L-cysteine along with L-glutamic acid and glycine is the rate-limiting precursor in the synthesis of GSH peroxidase and has been found that high concentrations of L-cysteine reduced the tyrosinase activity and produced more pheomelanin by way of cysteinyl dihydroxyphenylalanine (DOPA), the building block of pheomelanin [Figure - 1]

Likewise, knockdown of nNOS using siRNAs protects dopamine neurons in cell and animal models of PD 20

These results suggest that L-asp-induced glutamine depletion may play an important role in the treatment of AML patients

Targeting Nrf-2 is a promising intervention approach for the prevention of ethanol-induced liver disease