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Interestingly, these compounds also impair nuclear localization and enhance AR degradation, thus providing a multi-pronged approach that might overcome all new somatic mutations that arise during the course of the disease 199

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Conflict of interests The authors declare that there are no conflicts of interest

In contrast, phosphorylation of serines 215 and 793, by Akt kinase, was found to prevent nuclear translocation and receptor transactivation (93)