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The androgen receptor (AR) transcription factor activity is regulated by PTEN loss, which in turn inhibits androgen-responsive gene expressions

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Since B-017 and the negative control peptide were coupled with Cy5.5 fluorophores, the excitation wavelengths of the light sheets were set to 639 nm, and the corresponding 680/30 band-pass emission filter was used

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Microbial-derived metabolites, including but not limited to SCFAs, exert distal immunomodulatory effects through systemic circulation and vagus nerve signalingnotably regulating Treg cell differentiation and suppressing neutrophilic infiltration in bronchial tissues via G protein-coupled receptor (GPCR) signaling pathways ( 2 Methods 2.1 Search strategy To identify published studies, we conducted a comprehensive search of PubMed and Embase databases, covering records up to January 2025