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As a damage-associated molecular pattern (DAMP), HMGB1 activates immune cells to amplify inflammation through the release of multiple cytokines or chemokines[107]

FIGURE 2 Succination of GPX4 Succination was discovered in 2006 as a non-enzymatic, irreversible protein modification ( Ubiquitination of GPX4 Ubiquitination is a reversible process in which the ubiquitin is added to lysine residue(s) of the substrate protein by three different types of enzymes, E1, E2, and E3

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While protein secretion has long been studied in Gram-negative bacteria, our understanding of the secretion of additional extracellular materials is less complete 28,29,30

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