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Comparison of the efficacy and safety of new oral anticoagulants with warfarin in patients with atrial fibrillation: a meta-analysis of randomised trials

Under-methylation Under-methylation occurs when the synthesis of SAM in the methionine cycle is disturbed

doi: 10.1038/s41588-018-0248-z [DOI] [PMC free article] [PubMed] [Google Scholar] 73

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While systemic dihexa half life remains one to two hours, CNS concentrations may persist for four to six hours because the peptide is delivered to the target site without requiring blood-brain barrier penetration