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Among the limitations of this Evidence-Based Guideline, we acknowledge that the certainty of the evidence was not as high as desired for several of the recommendations and is probably biased by the scarcity of RCTs

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More recently, however, the link between the redox active components of GSTP1 and stress-activated kinases, such as JNK, has been redefined as a non-catalytic, ligand binding activity that mediates both stress and apoptotic responses