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These precision editing modalities represent significant advances over conventional CRISPR-Cas9 nucleases, particularly in post-mitotic hepatocytes where HDR is inherently inefficient

Khan MdA, Zafaryab Md, Mehdi SH, Ahmad I, Rizvi MMA

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99,100,101 A study analysing 21 brain metastases and their matched primary breast cancer showed that BCBM tends to have high genomic-aberration-based-homologous recombination deficiency (HRD) scores compared with their primary tumour counterparts, which indicates that brain metastases might be more sensitive to PARP inhibitors than their corresponding primary tumours

This analysis indicates that the P