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However, two cases of transient and mild adverse effects, including nausea and headache, were reported during the initial phase of treatment [145]

doi: 10.1073/pnas.1016650108 138 PannickeT.WurmA.IandievI.HollbornM.LinnertzR.BinderD

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A new derivate of DOX, 4-acetyl-2-nitro-benzenesulfonyl doxorubicin (ANS-DOX) was synthesized and shown to be converted into DOX by MGST1 and GSTA1-1, whereas no activity was observed for GSTP1-1 128