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Melanotan II: A synthetic peptide that stimulates melanin production (tanning) and was also studied for sexual arousal effects

Patient reports 15% pain reduction, insufficient for functional restoration. Imaging reports correlate symptoms with anatomic findings

High NNMT expression is closely associated with glucose dysregulation: excessive NNMT activation disrupts nicotinamide metabolism, lowers NAD+ levels, impairs insulin signaling, reduces cellular glucose uptake and utilization, and promotes hyperglycemia and insulin resistance