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Furthermore, ROS-mediated activation of the MAPK pathway enhances VEGF expression, and VEGF, along with its receptors (VEGFR1 and VEGFR2), promotes angiogenesis, cell survival, and adaptation to hypoxia via MAPK signaling and direct activation of HIF-1

Vitamin D, produced locally by monocytes, results in a shift in the immune status from proinflammatory to tolerogenic and regulates CD4 + T-cell responses by suppressing T helper (Th1) cell function and decreasing proinflammatory cytokines production, as illustrated in Fig

10.1016/j.lfs.2022.121127 314 ZhangX.WuS.GuoC.GuoK.HuZ.PengJ.et al (2022c)

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S73 | METXBIODB | Metabolite Reaction Database from BioTransformer | DOI:10.5281/zenodo.4056560 In an average-sized adult or child above the age of 9, the half-life of caffeine is approximately 5 hours