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Furthermore, WB analysis was conducted on extracts from the aortas of aging mice, showing consistent results with in vitro experiments: increased expression of p-P53 and decreased expression of total P53 after FOXO4-DRI treatment

While ROS were also increased by day 2 post-stimulation, restoration of PPP activity and redox homeostasis using galactose by 48 h did not restore antibody production so long as glycolytic flux was suboptimal

Nutrients 13 , 814 (2021)

I can never guarantee we can even get to the root cause

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