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Estrogen levels that are too high or low can also make it difficult for a woman to ovulate and become pregnant

10.1016/S0027-5107(01)00091-4

The Sham group showed negligible proteoglycan loss Discussion Osteoarthritis (OA) is a degenerative joint disease that is characterized by cartilage degradation, subchondral bone remodeling, and chronic inflammation, with no effective disease-modifying treatments currently available [33, 34]