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thus, it changes the activity of enzymes ( Figure 2

Virtanen JK, Hantunen S, Lamberg-Allardt C, et al

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Additionally, ROS can also trigger other cell death events in lens epithelial cells, such as apoptosis characterized by upregulation of the pro-apoptotic Bcl-2-associated X protein ( BAX ) gene and downregulation of the anti-apoptotic B-cell lymphoma-2 ( BCL-2 ) gene [30] as well as pyroptosis mediated by ROS-induced activation of the NLRP3 inflammasome/caspase 1/gasdermin D pathway [31]

2018 Feb 5;9