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10.1016/j.yjmcc.2011.10.011 52 LeeJ.LimJ

Both activation of PPAR by FAs and peroxisome proliferator-activated receptor gamma coactivator 1 (PGC-1) as well as increased PPAR expression increase the binding of PPAR to PPAR response elements on promoters of genes encoding for proteins involved in FA uptake and oxidation, including carnitine palmitoyltransferase 1 (CPT1) and long chain acyl-CoA dehydrogenase (LCAD) as key enzymes of FAO [30]

Moreover, the intervention significantly reduced Falls Efficacy Scale scores and exhibited a trend toward decreased fall incidence, thereby improving postural balance, lower-limb neuromuscular function, and motor confidence, ultimately reducing fall risk in this population (Thiel et al., 2025)

The adenosine moiety binds down into a hydrophobic pocket, with the ribose phosphate groups pointing outside towards the GTP allosteric site

Normal thyroid status is dependent on adequate levels of many trace minerals for the synthesis and metabolism of thyroid hormones