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GH also activates the MAPK/ERK pathway through Shc recruitment, the PI3K/AKT/mTOR pathway through IRS adaptors, and Src family kinases through a JAK2-independent branch

While standard atmospheric pressure on Earth represents about 6 10^22 hydrogen atoms pushing down on every square meter at Earths surface, and while the best terrestrial vacuum chambers can get down to about one trillionth of that, interstellar space has a pressure thats millions or even billions of times smaller than that!