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Polydatin does not act via direct binding to NLRP3, but rather by disrupting its chaperone-mediated stabilization, providing an alternative way to interfere with NLRP3mitochondria signaling platforms

Constipation is another common issue, reported in 21-25% of retatrutide users and a significant percentage of cagrilintide users

doi: 10.3389/fmicb.2025.1685962 Received 28 August 2025 Accepted 27 October 2025 Published 12 November 2025 Volume 16 - 2025 Edited by Vikash Kumar, Central Inland Fisheries Research Institute (ICAR), India Reviewed by Sijie Wang, Affiliated Hospital of Guangdong Medical College Hospital, China Xuchang Zhou, The First Affiliated Hospital of Xiamen University, China Updates Copyright 2025 Wang, Xu, Zha and Wu