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Mouse cerebellar astrocytes protect cerebellar granule neurons against toxicity of the polybrominated diphenyl ether (PBDE) mixture DE-71

On the other hand, oral supplements have to go through the gastrointestinal tract

Maneb is a carbamate fungicide that has been shown to cause mitochondrial damage (Zhang et al., 2003)

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They all use SAM as a substrate and they all produce S-adenosyl-homocysteine(SAH) as a product and this presents the cell with an important regulatory problem