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However, these lesions can also be induced in both rats and mice after viral infection (Bergs and Scotti 1967) or exposure to certain drugs or chemicals (Mendenhall and Chedid 1980

Participants were not randomized but were classified according to APOE genotype, clinical diagnosis, and biomarker status

In addition, mitochondria modulate intracellular calcium homeostasis and immune regulatory pathways (420, 421), which means these pathways may too be compromised in ME/CFS