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Briefly, mice bearing TSC2 -/- ELT3 xenograft tumors were treated every other day for 5 days with vehicle or rapamycin (1 mg/kg on day 1, 3, and 5) and tumors were harvested for metabolite extraction, as above, 3 h after the final treatment

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(2021) The aetiology and molecular landscape of insulin resistance

We then performed another in vivo experiment in which mice ( n = 10/group) were rendered diabetic (i.e., three consecutive readings above 250 mg/dL) prior to THR-123 (20 mg/kg) or saline administration