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Naturally, all of these factors can contribute to the rise in injury risks

Carmeliet P, Dor Y, Herbert JM, Fukumura D, Brusselmans K, Dewerchin M, et al

Outdoor rinks are naturally exposed to more dirt and debris than indoor rinks

Therefore, folate and cobalamin deficiency may decline hepatic levels of SAMe and phosphatidylcholine (PC) 6

For cell models in need of external metabolizing systems such as S9-mix, NAs are already activated extracellularly and the activated/reactive metabolites must cross both cell and nuclear membranes for DNA adduct formation