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During the last step of the matrix protein import cycle, PEX5 is recycled back into the cytoplasm in a monoubiquitin-dependent manner for further rounds of import or is subjected to proteasome-mediated turnover of dysfunctional receptors 49

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Azelaic acid, ascorbic acid, kojic acid, arbutin, chemical peels, and laser therapy also offer benefit but none of these therapies have shown uniformly satisfactory results