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Despite the studys scarcity, calpains inhibition has been suggested as an attractive antitrypanosomatid approach even without the confirmation of their proteolytic activity in these parasites

10.3945/jn.109.114249 33 HartmannP.ChuH.DuanY.SchnablB

Moco is synthesized de novo by a multistep metabolic pathway involving four genes: MOCS1 , MOCS2 , MOCS3 , and GPHN (see Figure 1 )

Conclusions Our study reveals SLC25A39 as a critical regulator of HCC progression via the mitochondrial ROS-cytochrome c -caspase signaling axis, highlighting its potential as a diagnostic biomarker and therapeutic target in HCC