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Cartilage degeneration was scored using the Yoshimi scale, which ranges from 0, defined as normal cartilage, to 5, defined as complete loss of cartilage

By blocking NNMT, it helps preserve NAD+, a vital coenzyme your cells need for energy production and DNA repair

NNMT inhibitor caused weight loss and reduced adipose tissue mass in DIO mice Since in vitro studies showed 5-amino-1MQ to have high cell permeability, enzyme selectivity, and cell culture efficacy, a sub-chronic (11-day) proof-of-concept in vivo study was conducted to test the effect of NNMT inhibition on obesity in HFD fed mice

It has a role in creatine synthesis which is a nutrient found primarily in muscle tissue

If you are using oral capsules, skip this section