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When the protein folding capacity of the endoplasmic reticulum is overwhelmed, it triggers an unfolded protein response that, if prolonged, can lead to inflammation and the apoptosis of insulin-producing cells and insulin resistance

Children with RS grow slower than typically developing children [364]

Therefore, publication bias is unlikely to have a major impact on the overall findings of this meta-analysis

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To estimate molar concentrations a 1:1 ratio was employed