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When comparing the responders from the CRWP group ( n = 12) to the non-responders in the same group ( n = 7), there was a significant difference in age with the responders being significantly older (4.23 0.22 years) than non-responders (3.48 0.18 years

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The large flexibility of GSH can be the weak point of the classical potential energy surface calculations, because the most reliable initial conformations are difficult to find

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