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These effects could be more pronounced with concomitant use of Hydrocodone Bitartrate and Acetaminophen Tablets and both CYP3A4 and CYP2D6 inhibitors, particularly when an inhibitor is added after a stable dose of Hydrocodone Bitartrate and Acetaminophen Tablets is achieved [see WARNINGS]

Difference between groups was analyzed by Two way ANOVA from GraphPad Prism-6.0

It is a dual agonist that activates both the GIP and GLP-1 receptors, and in research models this dual mechanism drives more pronounced changes in appetite signaling, gastric emptying, and glucose handling than single GLP-1 agonists