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Aspirin is known to cause a concentration-dependent inhibition of this pathway in vitro (Bos et al, 2006)

How JAK Inhibitors Are Used Topical JAK inhibitors (like ruxolitinib) are applied directly to affected skin areas, making them more suitable for localized vitiligo

Upon ligand binding, this presumably membrane-bound receptor transduces intracellular chemical/redox signals that relay messages for the regulation of gene expression, a phenomenon mainly involving the activation of transcription factors [2, 13, 14, 1618, 26, 34, 51, 70]