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Clinical translation of the developed PLGA-based nanosystems encapsulating conventional drugs and/or bioactive phytochemicals remains a challenge due to limited clinical trials validating the safety and efficacy of PLGA nano-systems

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GPCR-specific autoantibody signatures are associated with physiological and pathological immune homeostasis

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Future research should prioritize personalized VNS therapies, leveraging closed-loop systems integrated with multimodal biomarkers (e.g., EEG-gated taVNS) to dynamically optimize stimulation in real-time (123)

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Long-term use of NSAIDs may lead to side effects on the cardiovascular system, gastrointestinal tract, and kidneys, such as increased risks of heart disease, indigestion, gastrointestinal ulcers, bleeding, and reduced kidney function

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Kalia SK, Kalia LV, McLean PJ

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