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The normal substantia nigra contains twice as much copper as other brain regions, suggesting that copper plays an important role in this brain area (116)

In contrast, ferroptosis suppressor protein 1 (FSP1, also known as AIFM2) can potently inhibit this form of cell death (Doll et al., 2019) by inducing coenzyme Q10 (CoQ10) production and thereby suppressing lipid peroxidation (Bersuker et al., 2019)

Such studies will help distinguish whether it is gut microbiota dysbiosis-induced iron overload that affects chondrocyte ferroptosis and how, potentially, via lipid peroxidation or GSH loss