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Increased IOP induces the alteration of the functionality of antioxidant enzymes such as superoxide dismutase, catalase, or glutathione peroxidase, exacerbating the effects of mitochondrial damage (Moreno et al., 2004

These changes ultimately impair neuronal function and cause cell death

Tanabe S, OBrien J, Tollefsen KE et al (2022) Reactive oxygen species in the adverse outcome pathway framework: toward creation of harmonized consensus key events

MS/MS data were extracted and searched against in-house Mascot Server (Revision 2.5.0), a search engine that uses mass spectrometry data to identify and characterize proteins from sequence databases