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Excessive mitophagy with lower levels of biogenesis can burden the remaining mitochondria with too high energy production, thereby leading to excessive ROS and ultimately cell death (Schofield and Schafer, 2020)

Polypeptides of the invention which comprise a signal sequence have an N-terminus beginning within 5 residues (i.e., + or 5 residues, or preferably at the 5, 4, 3, 2, 1, +1, +2, +3, +4, or +5 residue) of the predicted cleavage point

Endoplasmic reticulum aminopeptidase 1 (ERAP1) polymorphism relevant to inflammatory disease shapes the peptidome of the birdshot chorioretinopathy-associated HLA-A*29:02 antigen