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Drug-Drug Interactions and Polypharmacy: Many oral chemotherapy agents are substrates, inhibitors, or inducers of cytochrome P450 enzymes , particularly CYP3A4 , which plays a central role in hepatic drug metabolism

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For individuals at moderate risk of gastrointestinal complications, combined therapy of NSAIDs with a gastroprotective agent should be considered

2014;5(5):e1249

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