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As illustrative examples of this, we tested two environmental toxicants PFOS (a surfactant in non-stick cookware and firefighting foam) and MEHP (a bioactive metabolite of a ubiquitous plasticizer)

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IGF1 indirectly increases DNA repair by 50% through increasing the p53 dependence in the p21, while inhibition IGF1R by siRNA in human prostate cancer cells enhances the sensitivity of ionizing radiation to SSBs and DSBs (Turney et al., 2012)