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Pharmacokinetic studies of recombinant human insulin-like growth factor I (rhIGF-I)/rhIGF-binding protein-3 complex administered to patients with growth hormone insensitivity syndrome

Carelli V, Sabatelli M, Carrozzo R, Rizza T, Schimpf S, Wissinger B, Zanna C, Rugolo M, La Morgia C, Caporali L, Carbonelli M, Barboni P, Tonon C, Lodi R, Bertini E (2015) Behr syndrome with OPA1 compound heterozygote mutations

All claims distinguish FDA-approved indications (none for muscle growth in healthy adults) from investigational or off-label uses

10.1007/s12017-013-8270-x 271 YiT.GaoP.ZhuT.YinH.JinS

For a direct comparison of these two peptides beyond reconstitution, see the complete semaglutide versus tirzepatide analysis