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Eumelanin is responsible for brown to black color and provides the darker skin tones

doi: 10.1128/mcb.00221-14 24 JiangLKonNLiTWangSJSuTHibshooshHet al

Glutathione is particularly susceptible to oxidation

In vitro experiments further disclosed the inhibitory effect of sUA on the monocyte Toll-like receptor (TLR) signaling pathway, which in turn reduces the migration capability of classical monocytes ( Macrophages Macrophages in most tissues have diverse functions, including initiating immune and inflammatory responses toward pathogens, maintaining tissue homeostasis, and contributing to tissue repair and remodeling ( Figure 2 )

Horne, Marianne J