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In negative ion mode (Supplementary Figure 2), the metabolite with the highest increase in the DSS group was Glucoputranjivin (log2FC = 3.77), and the metabolite with the highest decrease was Piperonal (log2FC = 4.56)

This interaction is thought to activate key biological pathways involved in wound healing, collagen synthesis, hair growth, immune function, and angiogenesis (the formation of new blood vessels)

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