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Although, in general, response rates to sildenafil are high, depending on the underlying cause of ED, up to 20%40% of patients may fail to respond to the phosphodiesterase type 5 (PDE-5) inhibition, and one recent report based on a limited telephonic survey suggests that 10%27% of men may need to increase the dose of sildenafil to maintain effectiveness over time, and 12% of men discontinue this medication for lack of efficacy within 2 years

It is general for cells to undergo epigenetic alterations after toxic treatment, but these changes include different trends and mechanisms

The site of attachment in human rhinovirus 14 for antiviral agents that inhibit uncoating

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Ethical approval Informed consent was obtained from all individual participants included in the study