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Although pain has never been considered a primary symptom of PD, several researchers, including Charcot 17 , had already referred to painful aspects of the disease: Sometimes Parkinson's is preceded by neuralgic or rheumatoid pains, which are occasionally of great intensity, being located in the extremity (...) that will soon be affected (...) by the convulsive agitation

Remember, GGT is just one piece of the puzzle

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In short, CST IV-AV is dominated by Lactobacilli and anaerobic bacteria, while CST IV-BV is characterized by BV-associated bacteria and high anaerobic diversity (Shen-Gunther et al., 2025)

It also activates the PI3K/PKB/Akt pathway, influencing cell functions [10-11]