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the main factors that are generally associated with elevations of homocysteine are nutritional deficiency, particularly related to folate metabolism, mutations of the enzymes MTHFR and CBS (Aguilar)

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For example, studies showing antioxidant benefits often use doses higher than those found in over-the-counter supplements

Dysfunctional mitochondria generate excessive ROS, mtDNA instability, and oncogenic signaling

It suggests that removal of the spleen might alleviate some aspects of oxidative stress (particularly nitrative stress), even as it exacerbates others (like iron deposition in the liver, as seen by ALT increase)