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This enables GPX4 to utilize GSH to reduce elevated ROS and detoxify lipid peroxides ( Porphyromonas gingivalis , a keystone pathogen in periodontitis, weakens the oral epithelial barrier and exacerbates the severity of the disease by inducing ferroptosis through inhibiting the SLC7A11/GSH/GPX4 axis ( Nicotinamide adenine dinucleotide phosphate oxidase 2 (NOX2

Understanding these factors can help differentiate between expected physiological changes and symptoms requiring medical attention

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