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A 400 mg/kg dose of Aerva javanica root extracts restored elevated biochemical markers and acute tubular necrosis by increasing GSH, and tissue protein levels and decreasing the TBARS concentration [62]

N-acetylcysteine has documented hepatoprotective properties in acetaminophen toxicity and non-alcoholic fatty liver disease by supporting endogenous glutathione synthesis

Furthermore, possible therapeutic measures are discussed, including probiotics, prebiotics, dietary modifications, antibiotic interventions, as well as fecal microbial transplantation, aiming to exert beneficial effects on NIU progression by reshaping the gut microbial composition