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Despite gametocytemia being an important predictor of transmissibility to mosquitoes, other regulators such as human host, parasite, mosquito, drug and environmental factors may play important roles

The field requires comprehensive single-cell resolution mapping of AT microenvironments, longitudinal studies tracking dysfunction development from early metabolic stress to established disease, and systems-level integration of multi-omics data to identify causal relationships in metabolic regulation

Notably, by directly depleting SLC7A11, p53 decreases the activity of xCT to boost ferroptosis[151]

Recent investigations also emphasize the impact of mitochondrial damage induced by ROS on several neurodegenerative illnesses, underscoring the critical significance of energetic malfunctions [21]