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Role of bone marrow derived cells in the development of Ewings sarcoma

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Houlston R Article: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE

Mechanistically, peroxynitrite has been shown to have 2 distinct mechanisms of action in its interaction with NOS: it can either uncouple the enzyme by oxidation of bound BH 4 or abolish enzymatic function by oxidative destruction of the NOS heme site, thus rendering an inactive enzyme, as opposed to one that is uncoupled 49,50