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Rapamycin-induced autophagy ameliorates GSH depletion-induced premature cell senescence It was shown that autophagy activation especially in the presence of an increasing autophagic flux inhibits the senescence of RPE cells 35,36,37,38,39

Krukowski K, Chou A, Feng X, Tiret B, Paladini MS, Riparip LK, Chaumeil M, Lemere C et al (2018) Traumatic brain injury in aged mice induces chronic microglia activation, synapse loss, and complement-dependent memory deficits

Second, the MGBA is bidirectional and the gut highly modulates, as much as the brain influences, state of gut physiology

Sindhuri R, Mohan R , Surendran P, Saranya R

Tavares AJ, Poon W, Zhang YN, Dai Q, Besla R, Ding D et al (2017) Effect of removing Kupffer cells on nanoparticle tumor delivery