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Moreover, folate deficiency might contribute to the increased coronary risk associated with the thermolabile MTHFR mutation (Hopkins et al, 1995

Benfotiamine in diabetic polyneuropathy (BENDIP): results of a randomised, double blind, placebo-controlled clinical study

Kiel, S., Amano, K

For someone who already has a reason to lose weight or lower blood sugar, a GLP-1 drug carries established metabolic and cardiovascular benefit along with the observational signal toward lower dementia risk described above, which makes it reasonable for those primary reasons

These anecdotal long-term outcomes suggest that for some EDS patients, prolotherapy serves as a form of maintenance therapy, not a one-time cure, but a reliable way to keep joints functional and pain-controlled by continuously reinforcing the lax ligaments