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10.1016/j.cmet.2016.10.011 130 YangW

Core mechanismsimmunomodulation (NF-B/COX-2 and downstream cytokines), antioxidant defense (Nrf2/HO-1 and redox homeostasis), and antimicrobial/anti-biofilm actions (including photodynamic synergy)are active across multiple oral conditions

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It serves multiple critical functions in hepatic health, acting as both a direct antioxidant and a cofactor for various detoxification enzymes

Ongoing trials and regulatory developments in MASLD Significant advances have been made in the clinical development pipeline for MASLD, with several therapeutic agents progressing to late-stage trials and achieving key regulatory milestones